I have an ensemble cast, protagonists and antagonists, and I love designing new characters of any type and bringing them to life. The antagonists, especially the really villainous ones, can be tougher to design. Some are fun to write and some make me super uncomfortable.
One of the regular “villains” has his own moral compass. He likes things orderly and likes control. His character is somewhat based on the mentality of slave owners and historical upper class, believing in the superiority of the wealthy and also a duty to guide, care for, and keep the lesser people in their place. He is quite dislikeable but as he also conflicts with other “villains” on a moral level, it makes for an interesting dynamic.
Others have their own priorities and motivations. I often have a historical type or figure in mind when I write for them. I have one character that I had to read the creepiest of rants from MRAs to develop. Another one of the second tier antagonists is a very intelligent and skilled “all business” type. I have others at that level who are hot-headed brats or power-mad sadists. All are unique, though.
My latest antagonist is a fun-loving, material guy, who can have fleeting anger/frustration but is all about enjoying moments, accumulating possessions, and living big. Honestly, he's one of the most fun characters to write. He's not malicious but he is callous. In another work, he would be the starting point of an anti-hero. (But at this point, I have no intention of him “changing his ways.”)

In short, both. There's room in the webcomic world (or in a single work) for despicable villains all can rally against and for misguided or complicated antagonists that readers may pity or enjoy or hope for redemption.